Superlines for Rapid Innovation

GeneNeer’s Superlines are the next generation of gene-editing technology, facilitating crop enhancement and innovation, providing growers a powerful tool to fortify their produce against the impacts of rapid climate change, including pests, viruses, fungi and other natural threats.

Gene Expression
with Precision and Control

Superlines offer an effective method of introducing and controlling gene expression in response to external application of specific metabolites, with a high degree of specificity. As a result, GeneNeer’s Superlines have the potential to become an increasingly popular tool for a wide range of applications in genetic engineering (introducing foreign genetic material into a genome) and genome editing (modifying native trait expression within a given genome).

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PREPARATION

GeneNeer technology
locks the trait
(Inactive)

TRIGGER

Drought
and other stresses

APPLICATION

Apply inducer via
irrigation or spray

ACTIVATION

Trait is active
for 7-14 days

Induction to
“Unlock” Tolerance Traits

The technology is based on an RNA regulatory element (RE), designed by GeneNeer, which acts as an inducible gene system. The RE is a short, non-coding sequence, which, when spliced into the mRNA in an inducer-dependent manner, “locks” the targeted trait. By externally applying an inducer, the RE “unlocks” the trait, activating its desired gene and controlling its expression.

Advantages of Gene Editing Based on GeneNeer’s Superlines

1

Competitive
edge

Customers gain a tool for rapid development and innovation of enhanced crop seeds.

2

Precise
control

Superlines’ RE can directly sense and respond to specific, nontoxic, low-cost metabolites.

3

Speed

Working from Superlines at the tissue-culture level eliminates the need for crossing or single-cell assays, thereby expediting response to impacts of climate change, and accelerating innovation.

4

Safety

GeneNeer’s technology enables complete control and extraction of the gene-editing machinery from the plant genome following editing, reducing the risk of off-target incidents.

5

Facilitating/
Enabling
technology

In the case of potatoes and sweet potatoes, GeneNeer’s approach facilitates/enables gene-editing.

6

Stackable

Multiple traits may be added to a single Superline™.

7

Scalable

Superlines can be applied to a wide range of crops.

8

Modular

Superlines’ RE can be employed in a wide range of applications, allowing for a high degree of flexibility in controlling gene expression.

9

Empowering

Providing crop growers the right seeds helps them produce greater abundance and more profitable yields, while contributing to global food security.